Circulating desialylated low density lipoprotein
نویسندگان
چکیده
منابع مشابه
Modified (desialylated) low-density lipoprotein measured in serum by lectin-sorbent assay.
Modified low-density lipoprotein (LDL) with a low sialic acid content was found in the blood of patients with coronary atherosclerosis. This desialylated lipoprotein causes lipid accumulation in arterial smooth-muscle cells and stimulates cell proliferation and production of the extracellular matrix, i.e., induces all atherogenic manifestations at the cellular level. We have developed a lectin-...
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Atherogenic modification of low-density lipoprotein (LDL) plays a crucial role in the pathogenesis of atherosclerosis, as modified LDL, but not native LDL, induces pronounced accumulation of cholesterol and lipids in the arterial wall. It is likely that LDL particles undergo multiple modifications in human plasma: desialylation, changes in size and density, acquisition of negative electric char...
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ژورنال
عنوان ژورنال: Cor et Vasa
سال: 2017
ISSN: 0010-8650,1803-7712
DOI: 10.1016/j.crvasa.2016.10.003